Real-Time Dosimetry and Optimization of Prostate Photodynamic Therapy

摘要

We have completed all specific aims of the project. We have developed motorized probe and associate software to characterization of optical properties in vivo in human prostate (specific aim 1). We have shown that the effective attenuation coefficient eff varied between 0.91 6.7 cm-1 (mean 2.9 +/- 0.8 cm-1), corresponding to an optical penetration depth (delta = 1/ eff) of 0.2 1.1 cm (mean 0.4 +/- 0.1 cm). We have made comparison of light fluence rate between calculation and measurement (specific aim 2) in 14 patients and have shown an agreement of 30%. We have developed the motorized probe and associate software to measure the distribution of optical properties, drug concentration, and StO2 interstitially using both absorption and fluorescence techniques (specific aim 3) and have verified the agreement between the two methods for determination of photosensitizer. We developed software to automatically optimize the light source weights, lengths, strengths in near real-time to improve the light fluence rate distribution in prostate and spare dose to critical structures (specific aim 4). In addition, we have developed a 12- channel beamsplitter for light delivery with motorized attenuators.