Caveolin-1 Modulates Androgen Receptor Signaling in Advanced Prostate Cancer

摘要

In the past funding year, we characterized a novel serinelthreonine p21 activated protein kinase 6 (PAK6) as a key signal mediator in regulating non-genomic AR signal transduction within membrane-associated caveoliniraft domain. We found that in prostate cancer cells androgen stimulation activates PAK6. Consequently, PAK6 activation promotes prostate cancer cell motility. Ectopic expression of constitutive active PAK6 in prostate cancer LNCap cells promotes ancharage-independent soft agar colony growth. Our results support the hypothesis set forth from our original proposal that AR signaling from raft to regulate its non-genomic function.