Biomolecular Motor-Powered Biosensor for Remote Detection Scenarios

摘要

The project is part of a collaborative effort between Sandia, the Naval Research Lab, the Albert Einstein Medical College, the ETH Zurich and the U. of Washington/University. of Florida to design a biomolecular motor-powered biosensor for remote detection of chemical/biological agents under the auspices of the DARPA-DSO Biomolecular Motors program. The project is continued by the PI at the U. of Florida under grant FA9550-05-1-0366. Significant advances have been made in the capture of analytes by and controlled activation of molecular shuttles powered by biomolecular motors, as well as their longterm-storage and simulation of performance. A testbed mimicking remote detection by LIDAR has been developed and applied. The project resulted in 5 journal publications and 9 oral presentations at national conferences and departmental seminars (6 invited) and the training of several students and postdocs.