IMPACT (Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular Targets and Complementary, Innovative and Therapeutic Modalities); Annual rept. 1 Feb 2005-31 Jan 2006

摘要

The projects in this proposal specifically target several signal transduction pathways known to be critical for NSCLC pathogenesis including the EGFR pathway and the more downstream ras/raf/Mek/ERK pathway. These projects combine targeted approaches using molecular and imaging techniques to validate activity against a target and monitor response using imaging modalities specific to the receptor using either small molecules or targeted peptlde approaches. The Developmental Research projects explore new areas including (1) the issue of high morbidity malignant pleural effusion thereby bringing the pulmonologists into the treatment of advanced disease with molecular therapies; and (2) prevention of lung cancer in youth through a highly interactive, entertaining CD-ROM program.