Interactions between Dietary Factors and Inflammation in Prostate Carcinogenesis

摘要

We are investigating whether inflammation can enhance prostate carcinogenesis in a rat model of dietary charred meat carcinogen induced cancers, and, whether antioxidant and other chemopreventative compounds can reduce prostate cancer in this model. We published a manuscript of some of the key data used for preliminary data in the original grant proposal. We completed part of aim 1 by treating PhIP treated Fisher rats with broccoli tea extract and celecoxib and discovered that both broccoli tea extract and the non- steroidal anti-inflammatory agent celecoxib prevents mutations in all lobes of the prostate in response to PhIP treatment. We also discovered that PhIP treatment causes widespread epithelial atrophy in the rat ventral prostate that precedes the development of PIN. We completed a long term study related to task 3 in which we will defined the baseline number and extent of PIN and intraductal cancer lesions in the 52 week model to be used for the remainder of the studies in task 3.