首页> 美国政府科技报告 >Role of the XIAP/AIF Axis in the Development and Progression of Prostate Cancer
【24h】

Role of the XIAP/AIF Axis in the Development and Progression of Prostate Cancer

机译:XIap / aIF轴在前列腺癌发展和进展中的作用

获取原文

摘要

In the past year significant progress has been made towards completing tasks both outlined in and extending beyond the original Statement of Work. The physical association between XIAP and AIF was determined to be highly dependant upon the ubiquitination status of AIF and XIAP-mediated ubiquitination of AIF was shown not to result in AIF degradation. It was determined that the XIAP antagonist Smac/DIABLO completely disrupted the association between XIAP and AIF in a manner that correlated with an increase in AIF ubiquitination. AIF was determined to be a substrate for cleavage by the serine protease and XIAP antagonist Omi/HtrA2 yet the absence of Omi/HtrA2 did not affect the cytoplasmic release of AIF following apoptosis induction. Interestingly the release of cytochrome c following cell death induction was shown to be delayed in cells deficient in Omi/HtrA2. Finally AIF was found to associate with the XIAP homologues cIAP-1 and cIAP-2 suggesting that AIF may be a general purpose IAP binding protein. These findings represent significant progress in further characterizing the interaction between AIF and the inhibitor of apoptosis (IAP) family and continue to form the basis for understanding how AIF and the IAP family contribute to the pathogenesis of prostate cancer.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号