Prostate Cancer Risk in Relation to IGF-1 and its Genetic Determinants: A Case Control Study Within the Cancer Prostate Sweden Project (CAPS)

摘要

Purpose and scope: A large genetic association study is being conducted to examine relationships of prostate cancer risk with polymorphic variation in a series of selected candidate genes that are involved in pathways determining the synthesis of IGF-I and IGF-binding proteins as well as biological response to IGF-I. The study is being performed within a large Swedish case-control study ('CAPS'). Progress report: We have distributed the selected DNA, selected haplotype tagging SNPs to be analyzed for all candidate genes and have completed about three quarters thirds of all genotyping assays for the prostate cancer cases and control subjects. We have completed analysis for the IGF1, IGFBP3, IGFBP1 and GHR genes using the linked database containing data on tumor grade stage and serum PSA levels for all prostate cancer cases. Associations with genetic variation in IGFI and GHR were noted. Plasma assays of IGF-1 and IGFBP-3 are also nearly completed. Conclusions: We have globally made very important progress on this project which will lead to a total of at least five scientific publications with the laboratory measurements produced thus far. However due to administrative errors in the transfer of funds we have been able to complete only about half of the genotyping assays that were originally planned. Proper receipt of the funding and extension of the study period by one year should allow us to complete the study fully according to the initial work plan.