Controlling Functional Group Architecture in Artificial Cells.

摘要

The goals and objectives of the period were to explore whether or not our triazole membrane synthesis system would allow for functional groups to be more predictably incorporated into phospholipid membranes spontaneously and also if the efficiency of incorporation can be improved compared to conventional methods. We also sought to utilize copper catalyzed cycloadditions to modify reactive groups within the phospholipid membrane structure and how the nature of the reactive elements, the copper catalyst, the azide, and the alkyne, affect the location and yield of the resulting product. The initial exploration of both these goals were performed and accomplished. We also developed a new methodology for synthesizing and controlling membrane architecture using light based approaches.