Role of Energy Metabolism in Cutaneous Sulfur Mustard Injury; Conference paper

摘要

Over the past 17 years, our research efforts have focused on systematic studies of the effects of sulfur mustard (2,2'-dichlorodiethyl sulfide, HD) on energy metabolism in human epidermal keratinocytes (KEK). Our objectives are to define mechanisms of HD-induced metabolic injury, determine their role in the cutaneous pathology observed and provide mechanistic information that can be used in development of vesicant agent medical countermeasures. We have characterized effects of HD on the major pathways of cellular energy metabolism in HEK. Our research has shown that inhibition of energy metabolism and depletion of energy stores are a significant consequence of HD exposure and that this inhibition is severe enough to be a determining factor in both cell survival and repair of HD-induced damage. In this paper we present an overview of our results and conclusions to date and briefly discuss their implications.