Pyridinium Oxime Compounds as Antimicrobial Agents.

摘要

Pyridinium oxime compounds have been utilised by a number of military organisations as one of the antidotes for nerve-agent poisoning. In Canada, the preferred compound from this class is HI-6, which has been demonstrated to be tolerated at high doses without significant ill effects. In this study, HI-6 and 15 structural analogues have been examined for their antimicrobial properties against a series of model organisms: Bacillus cereus and B. anthracis Sterue (as models for virulent B. anthracis), Ochrobactrum intermedium (as a model for Brucella spp.), Mycobacterium marinum (as a model for M. tuberculosis), and Crithidia luciliae (as a model for Leishmania spp.). In general, the compounds were found to have little to no antimicrobial effect, with KJD-2-11, a thiourea derivative, being the most active in all the test systems.