Microfabricated Multianalyte Sensor Arrays for Metabolic Monitoring

摘要

Glucose sensor arrays were fabricated on gold electrodes on flexible polyimide sheets by cross-linking glucose oxidase and redox polymer using UV- initiated free radical reaction. Using conventional silicon fabrication methods, five-element array Au microdisks were initially fabricated using mid-UV photolithography. Active glucose oxidase were entrapped by hydrogel by UV- intiated photo polymerization with poly(ethylene glycol) diacrylate or PEG-DA on the array electrodes. The fabricated microarray sensors were individually addressable and with no cross-talk between adjacent array elements as assessed using cyclic voltammetry. We have fabricated an array of glucose sensors on flexible polyimide sheets that exhibit the desired linear response in the biological range. We have also tested the sensors using other electrochemical methods including amperometry and square wave voltammetry (which is known for its background reduction).