Computerized Analysis and Detection of Missed Cancer in Screening Mammogram

摘要

This project is to explore an innovative CAD strategy for improving early detection of breast cancer in screening mammograms by focusing on computerized analysis and detection of cancers missed by radiologists. It is motivated by the facts that (1) it can be very instructive to review retrospectively the false negative results to determine why cancers were missed in mammographic screening; (2) some preliminary studies showed that there exist distinguishing features of missed cancer which is different from that of detected cancers. Significant progresses were made on data collection and analysis of characteristics of missed cancer in terms of its computational featured; missed cancer analysis with a focus on density analysis and its effect on CAD detection; new CAD system design; evaluation of the stand-alone detection sensitivity/specificity of the new CAD system; evaluation of the improvement of cancer early detection by using new CAD system. The results demonstrated the effectiveness of this study in improving detection performance.