首页> 美国政府科技报告 >Molecular Heterogeneity in Primary and Metastatic Prostate Tumor Tissue.
【24h】

Molecular Heterogeneity in Primary and Metastatic Prostate Tumor Tissue.

机译:原发性和转移性前列腺肿瘤组织的分子异质性。

获取原文

摘要

Purpose: The overarching goal of the grant was to characterize molecular heterogeneity in multifocal prostate cancer. Aim 1 focused on heterogeneity in PTEN loss in tumor tissue and prostate cancer prognosis. Aim 2 aimed to compare gene expression profiles between primary and lymph node metastases Scope: During the grant term, Dr. Batista received IRB approval, completed coursework to augment her expertise in prostate cancer epidemiology, coordinated meetings with collaborators, aided in specimen and data collection for the proposed work, lead the statistical analyses, and published the findings in peer-reviewed journals. Major Findings: PTEN loss was heterogeneous in prostate cancer foci, and was predictive of disease relapse. In related manuscripts that Dr. Batista co-authored and published, tumor expression of PSMA and genetic mutations in the SOD2 gene were associated with prostate cancer progression. Dr. Batista also published a review article on AMPK activation in cancer in Molecular Cancer Research. Significance: The clinical significance of the project was to better characterize putative prognostic markers for prostate cancer.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号