Identification of a Protein for Prostate-Specific Infection

摘要

In this proposal, we will identify and clone a protein that can be used to generate infection-specific gene therapy vector. We expect that using this protein to modify various gene therapy vectors, we can specifically deliver cytotoxic genes into prostate cancer cells using systemic treatment, and eventually eradicate metastatic prostate cancer cells in patients. In summary, although we worked very hard to perform the studies we proposed, we failed to achieve the expected results. In our application, we actually know the risk of this project. However, if we could identify the protein that is responsible for tissue-specific gene delivery, we should be able to develop a prostate-specific. By comparing the risk and the potential achievement, you proposed this project. Now the results demonstrated that the project is more difficult than we expected. Although we did not achieve the expected results, our effort produced publishable results as shown by one published paper and one submitted manuscript.