Characterization of Odin, a Novel Inhibitory Molecule, in EGF Receptor Signaling

摘要

Protein phosphorylation plays a key role in the regulation of the function of the proteins and the control of wild range of cellular process. Odin, one of signaling molecules identified in EGF receptor signaling pathway, functions as a negative regulator of growth factor receptor signaling pathways. To dissect the molecular mechanism of Odin in signaling pathway and its biological function, we employed SILAC methodology to identify 36 interacting proteins of Odin, 34 of which are novel. In the future, we seek to verify these interactions by in vitro and in vivo experiments. Since several interacting proteins of Odin play an important role in downregulation of RTK by endocytosis, we also want to examine the function of Odin and its phosphorylation in this process.