BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer

摘要

In this final report, I summarize the major accomplishments achieved during my three-year award period. Initial experiments focused on purification of endogenous BRCA1 complexes; however, the most fruitful work has occurred in characterizing the function of such BRCA1 complexes. I describe here distinct mechanisms for transcriptional stimulation and repression. These activities recapitulate the in vivo transcriptional functions of BRCA1.