Radiation Sensitization in Breast Cancer via Targeting Survivin Expression

摘要

We proposed to determine whether overexpression of survivin results in radioresistance and the possible mechanisms; whether regulators of survivin serve as targets for radiosensitization. We also found that deregulation of survivin in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of survivin and Stat3 results in significantly increased sensitization of breast cancer. In addition we found that inhibition of apoptosis induces autophagy in cell culture model of breast cancer. Z-VAD a pan-caspase inhibitor resulted in further tumor growth delay in a xenograft model of breast cancer.