10,000-Pen Nanoplotter with Integrated Ink Delivery System

摘要

This report summarizes major scientific and technological accomplishments during the three years of this grant. It includes an extensive list of articles published in peer reviewed journals and participation in scientific meetings, workshops, and lectures. Finally, patent disclosures, transitions, and awards earned by the participating investigators are listed. Over the three-year project period significant progress has been made in both areas. The Liu group took the lead in developing new DPN hardware and developed many advanced tools for SPL including 1-D and 2-D passive arrays, a 1-D active probe array, polydimethylsiloxane (PDMS) passive probes, a multifunctional active probe array and a microfluidic inking chip, and the development of electrostatic actuation probes. The advanced scanning probes and probe arrays that were developed under this program expanded the capabilities of scanning probe nanolithography (SPL) and have advanced SPL technology for commercial applications. Mirkin focused on the development of new DPN applications, in particular the development of protocols for the fabrication of electronically active nanostructures, for biodetection, and multiple-pen DPN, while the majority of important milestones was reached, as well as exceeded future challenges remain. Currently the main challenge in the field of Dip-Pen Nanolithography is to develop protocols for the fabrication of multi-component nanoarrays composed of different biological and chemical molecules.