Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury.

摘要

We hypothesize that the biomechanical perturbations of the brain that yield blast-induced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure (BOP) (i.e. primary blast) and head acceleration and/or impact (i.e. tertiary blast). The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.