Sonophoresis for Rapid Assessment of Interstitial Fluid and Drug Delivery.

摘要

The general objective of the proposed studies was to develop sonophoresis as a platform technology for assessing interstitial fluid from the skin and perform transdermal drug delivery. In this method, a short application of low-frequency ultrasound is used to extract biomarkers from skin. Ultrasound- permeabilized skin can also be used for transdermal drug delivery. Specifically, a drug patch can be placed on permeabilized skin to allow steady diffusion of drugs across the skin. Skin offers an excellent interface for diagnostics and drug delivery. However, low permeability of the skin limits our ability to harvest a sample of markers for diagnostics and to deliver drugs for therapeutic intervention. This challenge was addressed by ultrasound.