Met Nuclear Localization and Signaling in Breast Cancer

摘要

To explore the effects of exercise training on tumor vascularity and response to neoadjuvant therapy in operable breast cancer in a phase I-II randomized design. Method: Using a two-armed prospecbve randomized design potential participants will be identified and screened for eligibility via medical record review of patients scheduled for their primary neoadjuvant chemotherapy treatment consultation at DUMC. Following the successful completion of all baseline assessments participants will be randomly assigned to an exercise or control group. Pa rtici pants assigned to combined exercise training and chemotherapy will perform an individualized exercise training program consisting of three cycle ergometry sessions per week at approximately 60-80% of VO2peak on nonconsecutive days for the duration of neoadjuvant chemotherapy (approximately 12 weeks). Most Significant Research Finding During Reporting Period: As per our statement of work human ethnical approval was obtained (Task 1); all exercise testing 1 training procedures and clinical protocols were clarified (Task 2) and data collection has been initiated (Task 3). To date all 3 patients in phase I of the study have been enrolled and no dose-limiting toxicities have been identified with acceptable exercise adherence (>60%) thus phase II has been initiated.