Genetic Screen for Genes Involved in BRCA 1 Tumor Suppressor Function

摘要

Based on our initial screening, we have identified a number of candidates that are involved in DNA damage repair pathway mediated by BRCA1, which is an important aspect of tumor suppression of the molecular. As none of the candidates have previously been reported to play a role in DNA damage repair pathway we speculate that some novel components, such as RNA or chromatin structure, might be involved. Once verified and fully investigated, the possible target genes will contribute to the understanding of the biology of inherited breast cancer as well as the diagnosis and treatment of breast, ovarian and possibly other cancers.