Factors Influencing Outcome after Joint Replacement

摘要

This study will assess outcome after hip and knee joint replacement, testing the hypothesis that young patients are at increased risk for wear- related complications. We also hypothesize that periprosthetic bone loss, one of the most significant complications associated with implant wear, can be detected sooner and better monitored with routine follow-up that includes computed tomography imaging. Understanding the factors that influence the outcome of joint replacement procedures in the context of patient demands can help optimize surgical technique, implant selection, and post-operative management to insure the highest function and quality of life. Measuring implant wear and three-dimensional periprosthetic bone remodeling can help surgeons intervene at the appropriate time to prevent catastrophic implant failure. Institutional Review Board (IRB) approval for this study has been granted at the local level by Inova. We are currently working to obtain second level IRB approval from the United States Army Medical Research and Materiel Command (USAMRMC) Human Subjects Research Review Board (HSRRB). Although research work will not be initiated until IRB approval has been granted, we anticipate receiving second level approval in October 2007. As originally proposed, we expect that it will require 30 months to complete this research project once IRB approval has been obtained. Because we will not initiate research work until IRB approval has been granted, we anticipate filing for a no-cost extension corresponding to the period of time required to obtain IRB approval.