Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy

摘要

The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy.