Properties of Leukemia Stem Cells in a Novel Model of CML Progression to Lymphoid Blast Crisis; Final rept. 15 Sep 2005-14 Sep 2007

摘要

The objective of the study was to employ a novel mouse model of CML blast crisis to characterize various forms of leukemia stem cells (LSC) and their relative properties. In particular, distinguishing how differing normal target cells contribute to disease pathogenesis was regarded as an important priority in establishing relative heterogeneity of LSC.