Pathophysiology of Cutaneous Cafe-au-lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast-Synthesized Cytokines.

摘要

Fibroblasts derived from the CALM lesion of NF1 are capable of inducing melanin synthesis by normal human melanocytes as demonstrated in both an in vitro and in vivo model system suggesting that undefined cytokines are synthesized by NF1 fibroblasts putatively resulting in CALM.