Translating the Hibernation Phenotype to Human Trauma Care

摘要

Mammalian hibernators display two unique characteristics that can be exploited for major advancements in surviving blood loss: (1) metabolism is carefully manipulated to achieve controlled reductions in oxygen demand of tissues for energy conservation, and the effect is fully reversible; and (2) hibernators tolerate massive changes in cardiac function, ventilation, tissue perfusion/ reperfusion, and intermediary metabolism that have similarities to shock and other trauma states, yet they are fully protected. Our team-oriented project integrated physiology, pathophysiology, and functional proteomics and metabolomics to identify novel candidate protection strategies based on these characteristics. We demonstrated that hibernators are highly protected against severe blood loss and mesenteric ischemia-reperfusio injury, and we identified several candidate proteins and metabolites that may contribute to hibernation- induced protection in these models.