Genome to Phenome: Integromic Approaches to Define Networks of Host- Pathogen Interactions and Vaccine Biomarker Discovery

摘要

The rapid development of genomics, proteomics and high-throughput computing approaches to study diseases is now allowing us to apply an integrative systems biology work frame for drug and biomarker development. Understanding the symbiosis of pathogen and host at the molecular level requires a comprehension of the molecular/cellular events by which the pathogens can induce alterations in the host in order to invade, proliferate and overtake the host. Our research focuses on defining the molecular events/network systems involved in the host-pathogen interactions to identify biomarkers and therapeutic targets for pathogenic agents.