Determinants of Weight Gain in Women with Early-Stage Breast Cancer; Annual rept. 1 Apr 2007-31 Mar 2008

摘要

Weight gain after breast cancer diagnosis is common, and it has been associated with poorer prognosis. The goals of the study are to examine weight gain in relation to treatment-related changes in sex hormone levels, and to genetic polymorphisms in sex hormone pathways, accounting for potential interactions with energy balance, psychosocial factors, tumor characteristics, cancer treatment, and medication use. Since sex hormones and glucocorticoids regulate body weight and adipose tissue distribution, the authors hypothesize that sex hormones and cortisol play a role in treatment-induced weight gain, and that complex interactions exist with genetic susceptibility, lifestyle, and psychosocial factors. A prospective longitudinal study of weight gain is being conducted in 215 stage I to stage IIIA breast cancer patients. During the second year of this grant, a supplementary questionnaire was developed to examine temperature perception after breast cancer diagnosis and treatment. Study data bases were developed for data entry of this questionnaire. Recruitment and followup of participants have continued, with a total of 226 patients recruited into the study. Of these, 31 patients have withdrawn from the study and 5 were lost to followup leaving a total of 190 participants. The authors are in the process of double entering all data collected by survey and checking and clarifying any differences that exist. Participant recruitment using consent forms with DoD language began January 2007 after obtaining institutional IRB and USAMRMC Human Research Protections approval. Sixty-six participants have been re-enrolled using this consent form, with 9 refusing reconsent, and 16 still in the process of being reconsented. The study will help identify women who are most susceptible to weight gain after being diagnosed with breast cancer, based on biologic characteristics as well as modifiable factors.