Enhancing Quality of Life for Breast Cancer Patients with Bone Metastases

摘要

Current treatment for osteolytic breast cancer bone metastasis typically involves radiation therapy (RTX) to palliate bone pain and a bisphosphonate to inhibit osteoclastic bone resorption. The goal of this research was to determine the effects of zoledronic acid as an adjunct to RTX on restoring bone strength and density. We also investigated whether the combination of ZA and an anabolic agent (parathyroid hormone, PTH) as adjuncts to RTX further enhanced bone strength and thus decrease the risk of subsequent pathological fractures.