Loss of Pin1 Deregulates Cell Cycle Progression and Promotes the Development of Breast Cancer

摘要

Pin1 regulates many factors that are relevant to breast cancer, such as c-Jun, c-Myc, cyclin D1, and cyclin E. However the function of Pin1 in a normal cell is still poorly understood. Thus the role of Pin1 in G0/G1 to S- phase progression of the cell cycle was examined in this research project. The most significant finding was that Pin1 appears to be a novel regulator of the Rb signaling pathway.