Evaluation of Blood Cholinesterase Testing Methods for Military Health; Technical rept. Jul 2007-Feb 2008

摘要

Blood cholinesterase (ChE) testing is done to evaluate potential human exposure to chemicals that act as ChE-inhibitors, most often organophosphate and carbamates pesticides. The Model 400 Test-mate ChE kit (EQM Research, Inc.) is used for field blood ChE analysis within the Department of Defense. Suggested modifications to the Model 400 kit include displaying and recording acetyl-ChE activity uncorrected for temperature and using analytical standards for calibration or quality assurance purposes. The recent advent of a wide array of point of care devices may provide an opportunity for developing improved hand-held instruments field ChE analysis. If a hand-held device for field blood ChE analysis is developed for military health surveillance, a concept of operations for the device should be prepared as a first step. Some key performance areas for a field ChE device development are identified.