Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer; Final rept. 7 Jan 2007-6 Jan 2008

摘要

The P582S C->T and A588T G->A polymorphisms in the Hypoxia-inducible factor-1alpha (HIF-1alpha ) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP) During the course of our research we published that P582S polymorphism was not associated with CaP (see appendix). However we observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels >= versus.