Very High Dose-Rate Radiobiology and Radiation Therapy for Lung Cancer.

摘要

In this project we propose to experimentally characterize the radiobiological effectiveness of delivery times in the sub-second range using very high energy electrons (VHEE) on lung cancer cells in-vitro and in-vivo. To carry out the proposed project, we will use established procedures such as clonogenic cell survival essays for the in vitro studies to study the dose rate effects, and in vivo tumor growth delay assays to study the RBE of VHEE. For this purpose, we have established a unique multidisciplinary collaboration between Stanford University Department of Radiation Oncology and the Accelerator Research Division at Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory. Our in-vitro studies have demonstrated a statistically significant higher cell kill with fast irradiation times compared to conventional irradiation times. We have not observed a difference in cell survival between 60 MeV vs 120 MeV irradiations or between VHEE and photons