Prostate Dose Escalation by a Innovative Inverse Planning-Driven IMRT

摘要

The goal of this project is to develop innovative inverse planning techniques for prostate radiation therapy. In the last funding period significant progress has been made toward the goal of the project. In the past funding year, the PI group has continued to advance prostate radiation therapy techniques. A few important milestones have been achieved toward the goal of the project. These include: (i) Proposed a novel total-variation regularization based inverse planning technique for prostate IMRT; (ii) Applied compressed sensing concept to IMRT and IMAT inverse planning and established a multi- objective optimization framework; (iii) Developed a voxel-specific penalty scheme for TRV-based inverse planning; (iv) Established a cine-EPID image retrospective dose reconstruction in IMRT dose delivery for adaptive planning and IMRT dose verification. These works are both timely and important and should lead to widespread impact on prostate cancer management.