Pharmacological Studies of NOP Receptor Agonists as Novel Analgesics; Annual rept. 15 Apr 2007-14 Apr 2008

摘要

These experiments demonstrated that (1) intrathecal N/OFQ did not produced hyperalgesia-like effects as reported in rodents, (2) systemic Ro 64- 6198 produced antinociceptive effects that are independent from mu opioid receptors, and (3) activation of NOP receptors produced antinociception without reinforcing/abuse liability in monkeys. Ro 64-6198 has only been studied in rodent species. This is the first functional study to investigate the behavioral effects of Ro 64-6198 in primates. More importantly, Ro 64-6198 produces antinociception like alfentanil, a commonly used mu opioid analgesic in the clinic, in two primate nociceptive models, but Ro 64-6198 does not produce reinforcing effects /abuse liability like mu receptor opioid analgesics. These findings may indicate that NOP receptor agonists may be a new generation of novel analgesics without abuse liability.