Targeted Zinc Delivery: A Novel Treatment for Prostate Cancer; Annual rept. 1 Jun 2007-31 May 2008

摘要

At present, treatment for patients with advanced metastatic prostate disease or who progress to metastatic disease is limited. We proposed to initiate studies to develop and comprehensively evaluate targeted zinc loaded liposomes as a therapeutic for the treatment of men refractory to current treatment options. In the past year we have evaluated a number of zinc compounds and have shown that zinc acetate is suitable for entrapment into transferrin targeted liposomes. We have also developed a human xenograft model and have shown that intratumor injection of zinc solutions arrest the growth of the subcutaneous PC-derived tumors. This result is exciting and shows the potential of zinc as a prostate cancer therapeutic.