Role of Cyclin D1 in Altering Stromal-Epithelial Interactions in Prostate Carcinogenesis

摘要

To explore the role of cyclin D1 in prostate cancer progression, we manipulated cyclin D1 expression in both epithelium and stroma by retroviral infection and examined the role of cyclin D1 using a tissue recombination model. The data showed that over expression of cyclin D1 in stroma elicited a permanent malignant transformation of ajacent initiated epithelium by paracrine manner, instead of direct manner in vivo. The highly concordant gene expression pattern between prostatic carcinomoa associated fibroblasts and cyclin D1 over expressing fibroblasts allows for the rational design of therapies aimed at inhibiting prostate tumor growth by manipulating cyclin D1 expression in the relatively stable stroma.