Development of Therapeutic and Diagnostic Countermeasures to WMD by the Advanced Medical Countermeasures Consortium

摘要

Acute lung injury in rats following airway delivery of CEES is associated with loss of distal lung barrier function (resulting in alveolar flooring) and an intense inflammatory response, which is lung-damaging. These acute lung injury parameters are attenuated by neutrophil depletion or complement blockade. Injuring the redox balance in lung after exposure to CEES by administration into lung of liposomes containing antioxidant compounds is highly protective even when delivery of liposomes is delayed by at least 1 hr. CEES-induced lung injury is progressive, as manifested by development of interstitial fibrosis which seems to peak at three weeks. Whether STIMAL will attenuate development of lung fibrosis is currently unknown.