Effect of a High Bone Turnover State Induced by Estrogen Deficiency on the Development and Progression of Breast Cancer Bone Metastases

摘要

Aromatase inhibitors (AIs), effective treatment for breast cancer, block estrogen synthesis. Increased bone resorption and decreased bone mineral density (BMD) are predicted consequences. Four-week-old and 16-week-old female Balbc/ICR Swiss athymic mice were treated with the AI letrozole (5 mg/kg/day) or control. Four-week-old female athymic mice treated with letrozole for 16 weeks had increased BMD compared to control at the total body.