Investigating the Role of TBX2 in the Inhibition of Senescence in Prostate Cancer; Annual summary rept. 15 Feb 2007-14 Feb 2008

摘要

The aim of this project is to dissect the role of Tbx2 in prostate cancer progression. In the present study we have found that by reducing the expression of Tbx2 in prostate cancer cell lines reduces proliferation in vitro. Further, utilizing tissue recombination techniques we found that the grafts obtained from NeoTag-2 mouse prostate cancer cells containing the dominant negative Tbx2 construct are more differentiated as compared to controls. These findings suggest that inducing senescence by down-regulating Tbx2 may reduce tumorigenesis and hence Tbx2 plays an important role in prostate cancer progression.