Non-Invasive Markers of Tumor Growth, Metastases, and Sensitivity to Anti- Neoplastic Therapy; Annual rept. 6 Dec 2006-5 Dec 2008

摘要

The goals of this application are to develop methods to non- invasively differentiate fast and slow growing prostate tumors and also develop methods to evaluate response to anti-angiogenic agents. Validation of the results will be based on tumor growth metastases and microvessel density measurement (antiangiogenic studies). To date we have succeeded in demonstrating that the R3327AT rat prostate tumor which is relatively radiation resistant has detectable lactate which is heterogeneously distributed once the tumor exceeds 6OOmm3. In contrast the radiation sensitive slow growing Dunning H does not have lactate that is detectable by NMR. DCE-MRI studies do not suggest differences between slow and fast growing rat prostate tumors.