Mechanism of Tumor Metastasis Suppression by the KAI1 Gene; Final rept. 12 Jan 2004-11 Jan 2008

摘要

KAl1 is a tumor metastases suppressor gene which is capable of blocking the metastatic process without affecting the primary tumorigenesis. In this project we tested the hypothesize that the KAl1 protein on tumor cells interacts with gp-Fy (DARC) on the endothelial cells which activates a signal pathway of the KAl1 molecule and that this activation eventually leads to cell growth arrest of tumor cells. We originally planned to examined whether the interaction of KAl1 and DARC leads to suppression of tumor metastasis in vivo (Task 1) and identify specific peptide sequences that activate KAl1 and to assess the efficacy of the peptides on tumor growth in an animal model (Task 2). We have successfully completed Task 1 and published the results in Nature Medicine. Task 2 has been partly accomplished but there are some tasks remained. However we consider that our project has been overall quite successful and our original idea has been fully developed. The results of this project have led to successful ROl funding and we will continue to develop and expand our research.