Vitamin D for Cancer Prevention: Global Perspective.

摘要

The papers in this review support a role of vitamin D repletion in reducing incidence of cancer. Higher levels of the main circulating form of vitamin D, 25-hydroxyvitamin D 25((OH)D), were associated with lower risk of colon, breast, and ovarian cancer. There was a linear dose-response gradient above an approximately 25 ng/ml threshold, with few exceptions. Action is needed by public health officials and professional and voluntary organizations to recommend universal intake of 2,000 IU/day of vitamin D3 with a suitable dietary intake of calcium in populations residing at >30 deg. from the equator, starting at age 1 year. The evidence reviewed here indicates that such action will rapidly prevent a substantial proportion of cases and deaths from breast, colon, ovarian, and other cancers.