Two-Dimensional Deoxyribonucleic Acid (DNA) Matrix Based Biomolecular Computing and Memory Architecture

摘要

The primary goal of this research was the development of an enabling technology for DNA computing. It focused on the development of two distinct DNA- based nanotechnologies, aqueous computing and DNA arrays. Once merged, these DNA-based nanotechnologies serve as a platform for a hybrid silicon-DNA computing architecture. The aqueous side is where the computing happens and the array side is where the results are preprocessed. The array information passes to an electronic computer for signal processing type decoding. The intent was to develop a computing basis to overcome the exponential time complexity of many discrete mathematical problems so that they can be solved in linear real time. This research addresses needs of the Air Force because computationally hard (NP) problems are critical to logistics, scheduling and national security. Moreover, the DNA nanotechnologies developed in this research has the potential to enhance Biotaggants which provide environmental awareness in the field.