Synthetic Metabolic Channels for Improving Microbial Production of 1,2, 4-butanetriol

摘要

The long-term objective of our proposed studies is the development of a broad-spectrum platform for engineering complexes of metabolic enzymes in bacteria that is expected to dramatically improve the yield of virtually any biosynthetic target produced in microorganisms by accounting for enzyme organization and minimizing metabolic cross-talk. Related studies are currently funded under ONR YIP grant No. N000140610565 and focus on the production of 1,2- propylene glycol (1,2-PG). The objective of this particular application is to improve microbial synthesis of D-1,2,4-butanetriol (D-BT), a precursor to the energetic material D-butanetriol trinitrate (D-BTTN), using our technology for engineering metabolic complexes in living cells.