Resetting the T Cell Repertoire in Prostate Cancer Bearing Host.

摘要

This is the second annual report on the grant Resetting the T cell repertoire in prostate cancer bearing host. A major obstacle to effective anti-tumor immune response is immune tolerance to tumor antigens, mostly caused by the defective cancer-reactive T-cell repertoire and increased immune suppression by regulatory T cells. We proposed to reset the immune system of cancer-bearing host by rescuing cancer-reactive T cells and by eliminating the generation and survival of Treg. In the past funding period, we have published two papers that summarized our results from specific aim 2 in modulating Treg production in anti-tumor immunity. We have submitted the third paper in the role of lymphotoxin and its receptor in T cell negative selection. We applied the lymphotoxin receptor beta IgG Fc fusion protein to TRAMP prostate cancer mice and achieved the cancer preventive effect.