Characterization of Nanoparticles by Capillary Electrophoresis and Trapping of Nanoparticles in Microfluidics Device.

摘要

The contractor report describes research performed for Contract No. W7702-04R-021. The work was carried out in support of CRTI 03-005RD. The report describes the use of capillary electrophoresis (CE) as an analytical method for characterizing gold, polymer and iron oxide nanoparticles (NPs). The analyte species were detected by UV/vis or laser-induced fluorescence (LIF) spectroscopy. For analytes that possessed neither UV/vis absorbance nor LIF, indirect methods of detection were employed whereby a signal-generating molecular species was added to the running buffer. NPs from a variety of commercial sources and from custom syntheses were studied. The report demonstrates that CE is a valuable tool in NP research. The report also demonstrates the feasibility of trapping nanoparticles in microfluidic devices for sample clean up and detection.