Evaluating Surgical Margins with Optical Spectroscopy and Spectral Imaging Following Breast Cancer Resection

摘要

In one aspect of the fellowship, a training program has been established to expose the PI to a wide range of current breast cancer research, particularly through seminars in imaging and cancer biology fields. Collaborations with other graduate students and mentoring of undergraduate students has also been pursued. In the research portion, polarized fluorescence and reflectance-based imaging was initially pursued to examine breast tumor surgical margin status intraoperatively during breast conserving therapy. After achieving insufficient results, the approach was modified to spatially offset Raman spectroscopy (SORS) to achieve the proper depth sampling needed for the clinical procedure. Results thus far have shown the feasibility of the SORS approach for detecting breast tumor signatures under up to 2 millimeters of normal breast tissue. Efforts are currently underway to develop a Monte Carlo simulation model to further understand the results. Two full-length manuscripts, several conference talks, and a BCRP Idea Award have all grown from this work.