Disruption of the Circadian Rhythms of Gene Expression and the Development of Breast Cancer

摘要

This project investigated the effects of rhythm disruption in mice on the expression of a wide range of genes in mammary tissue, the growth of MCF- 7 xenografts and the growth, metastasis and gene expression in spontaneous mouse mammary tumors. Subjecting mice to a simulated shiftwork schedule altered the pattern and level of expression of clock gene transcription factors and genes that are involved in the cell cycle. We have also found that the formation of secondary lung tumors is enhanced by a simulated shiftwork protocol.